https://embed.notionlytics.com/wt/ZXlKd1lXZGxTV1FpT2lKbFptTXdOV0ppTVRkaVpHWTBaRGc0T1RFMFlqWXdNV1kzTnpSalpUazNZeUlzSW5kdmNtdHpjR0ZqWlZSeVlXTnJaWEpKWkNJNklsQnpWMW8yVjJSWGR6RjBNVWhRZG5OM2FreFNJbjA9

• A paper published in Nature Aging, found that the loss of sex steroid hormones produced by the enzyme 3-hydroxyl-steroid dehydrogenase, or 3-HSD, results in dry eyes in individuals over 60 years of age, but it can be treated with nicotinamidemononucleotide, or NMN, which is a non-steroid agent.
• There is a strong correlation between aging, a drop in sex-hormones, and the rise inage-associated incidence of meibomian gland disorder (dry eyes).
• The researchers, out of Kyoto University found that topically administering nicotinamide mononucleotide, or NMN, a precursor of NAD (nicotinamide adenine dinucleotide), elevates the amount of NAD needed to reboot 3-HSD activity.
• This is hopeful for this who suffer from dry eyes as they age.

Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction - Nature Aging